Can hepatitis C elimination targets be sustained among people who inject drugs post-2030?

Modelling the burden of hepatitis C infection among people who inject drugs in Norway, 1973–2030

BACKGROUND Lack of Hepatitis C virus (HCV) incidence data in (Norwegian) high-risk groups impedes the ability to make informed decisions on prevention measures. Thus we rely on modelling to estimate the incidence and burden of HCV infections. METHODS We constructed a compartmental model for HCV infections in Norway among active and former people who inject drugs (PWIDs). We based yearly trans...

Hepatitis C virus vaccines among people who inject drugs.

Most people who inject drugs (PWID) are infected with hepatitis C virus (HCV), and PWID have the highest risk of HCV infection of any risk group. The incidence of HCV infection is 5%-25% per year, demonstrating continued need for HCV infection prevention in PWID. Existing data in chimpanzees and PWID suggest that protective immunity against persistent HCV infection is achievable. Due to the hig...

A quasi-markov model for transmission and disease elimination: Hepatitis C among people who inject drugs

Background: The use of mathematic modeling to better understand the spread of Hepatitis C and the impact of interventions can be invaluable for localities, states and countries with a large burden of injection drug use. New York State (NYS) is estimated to be home to a large number of people who inject drugs (PWID), however the burden of hepatitis C among this population and the impact of inter...

to new hepatitis C therapies for people who inject drugs

Hepatitis C virus transmission in people who inject drugs: swabs may not be the main culprit.

TO THE EDITOR—We read with interest the recent article by Thibault et al [1], which described laboratory analyses of injection equipment collected from people who inject drugs in France. In particular, the detection of hepatitis C virus (HCV) RNA in 80% of pooled samples of alcohol and cotton swabs raises concerns about the possible role of swabs in HCV transmission. While the accompanying edit...